1-Ethylpiperidin-4-amine → HCID 71471760, compound

HRID 1506776Notes

Reaction equation

HRID 1506776 reaction equation
Cl[C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1[CH:14]=[C:13]([O:16][CH3:17])[CH:12]=[CH:11]3)=[CH:7][CH:6]=[CH:5][CH:4]=2.[CH2:18]([N:20]1[CH2:25][CH2:24][CH:23]([NH2:26])[CH2:22][CH2:21]1)[CH3:19]>>[CH2:18]([N:20]1[CH2:25][CH2:24][CH:23]([NH:26][C:2]2[C:3]3[C:8]([N:9]=[C:10]4[C:15]=2[CH:14]=[C:13]([O:16][CH3:17])[CH:12]=[CH:11]4)=[CH:7][CH:6]=[CH:5][CH:4]=3)[CH2:22][CH2:21]1)[CH3:19]

Participants

3

Reactant 2

HCID 37349901-Ethylpiperidin-4-amineHCID 124242049-Chloro-2-methoxyacridine

Product 1

HCID 71471760HCID 71471760, compound

Procedure

Following the general procedure of Example 1 and making non-critical variations but using 9-chloro-2-methoxyacridine and 1-ethylpiperidin-4-amine, the title compound was obtained; MS (Found M+1=336). 1H NMR (CD3OD, 400 Hz): 8.2.9-8.27 (d, 1H, J=8.8 Hz), 7.96-7.94 (d, 1H, J=8.8 Hz), 7.92-7.89 (d, 1H, J=9.6 Hz), 7.70-7.66 (m, 1H), 7.53 (m, 1H), 7.46-7.43 (m, 2H), 3.98 (s, 3H), 3.90-3.80 (m, 1H), 3.02-3.8 (bm, 2H), 2.46-2.41 (q, 2H, J=7.2 Hz), 2.05-2.00 (m, 4H), 1.93-1.83 (m, 2H), 1.11-1.08 (t, 3H, J=7.2 Hz).

Sources & evidence

ORD record
ord-9b25f50ea5384572b48bb6353c0781c3
Source dataset
uspto-grants-2015_12
Patent number
US09221760B2

Reaction notes

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