反应详情

Following the same procedure to synthesize 2-(2-amino-1H-benzo[d]imidazol-6-ylcarbamoyl)benzoic acid hydrochloride, tert-butyl 6-amino-2-(bis(tert-butoxycarbonyl)amino)-1H-benzo[d]imidazole-1-carboxylate (0.157 g, 0.351 mmol) was reacted with 4,4-dimethyldihydro-2H-pyran-2,6(3H)-dione (0.049 g, 0.351 mmol) to give the title product (0.107 g, 93% yield) as a yellow solid. 1H NMR (300 MHz, CD3OD) δ 7.81 (s, 1H), δ 7.29 (m, 2H), δ 2.45 (m, 4H), 1.16 (m, 6H) ppm; 13C NMR (75 MHz, CD3OD) 174.8, 173.6, 173.1, 171.9, 171.6, 151.2, 134.7, 129.6, 111.5, 103.9, 33.2, 33.1, 29.1, 27.3, 26.9 ppm; HRMS (ESI) Calcd for C14H19N4O3 (M+) 290.1378. Found 290.1380.