反应详情

Following the same procedure to synthesize 1-(2-amino-1H-benzo[d]imidazol-6-yl)-1H-pyrrole-2,5-dione hydrochloride, tert-butyl 6-amino-2-(bis(tert-butoxycarbonyl)amino)-1H-benzo[d]imidazole-1-carboxylate (0.161 g, 0.359 mmol) was reacted with (2-dodecen-1-yl)succinic anhydride (0.096 g, 0.359 mmol) to give the title product (0.142 g, 91% yield) as a yellow solid. 1H NMR (300 MHz, CD3OD) δ 7.46 (d, 1H), 7.28 (s, 1H), 7.19 (d, 1H), δ 5.62 (m, 1H), δ 5.47 (m, 1H), δ 3.19 (t, 1H), δ 2.99 (t, 1H), δ 2.65 (m, 2H), δ 2.06 (m, 2H), δ 1.63 (d, 2H), δ 1.28 (m, 14H), δ 0.89 (t, 3H) ppm; 13C NMR (75 MHz, CD3OD) δ 179.8, 176.9, 151.5, 134.9, 133.7, 129.4, 128.3, 124.9, 122.8, 111.4, 110.6, 40.2, 36.1, 34.9, 33.7, 32.5, 31.9, 29.6, 29.4, 29.1, 27.2, 22.6, 13.4 ppm; HRMS (ESI) Calcd for C23H32N4O2 (M+) 396.2525. Found 396.2522.