Ammonium Hydroxide → HCID 89907188, compound

Participants

Reaction Steps

A solution of 4.8 g 6-chloro-4,4-dicyclohexyl-4H-benzo[1,3]dioxine-2-carboxylic acid and 2.44 g 1,1′-carbonyl diimidazole in 122 ml THF was stirred for 2 h at room temperature. Then 122 ml 25% aqueous NH4OH was added and the reaction mixture stirred for 16 h at room temperature. The precipitate was filtered, washed with cold water and dried over P2O5. Recrystallization from EtOAc yielded the desired product. Yield: 3.55 g.

Provenance & Evidence