Potassium Carbonate → HCID 60155351, compound

Participants

Reaction Steps

To a solution of compound (8) obtained above (0.87 g, 4.4 mmol) in dry DMF (8.7 mL), potassium carbonate and chlorocyclopentanone (0.53 mL, 5.3 mmol) were added, and the obtained mixture was heated to reflux for 3 hours. After the reaction, the mixture was filtered and the obtained filtrate was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography and elution with an n-hexane/ethyl acetate (7:1) solution followed by conventional hydrolysis to give 0.28 g (32%) of compound (12) of interest as yellow oil.

Provenance & Evidence