HCID 60155537, compound → HCID 60155615, compound

HRID 1506882Notes

Reaction equation

HRID 1506882 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[C:5]([F:11])=[CH:4][C:3]=1[CH:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14]>C(O)C.[C].[Pd]>[NH2:8][C:6]1[C:5]([F:11])=[CH:4][C:3]([CH:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14])=[C:2]([F:1])[CH:7]=1

Participants

4

Reactant 1

HCID 60155537HCID 60155537, compound

Product 1

HCID 60155615HCID 60155615, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of compound (28a) (5.2 g, 21.2 mmol) in ethanol (96 mL), 10% palladium-carbon (0.52 g, 10% w/w) was added and treated under hydrogen gas flow in the same manner as in (d) in Production Example 1 to give 3.5 g (83%) of compound (29a) as red oil.

Sources & evidence

ORD record
ord-7f1f95e30b6441e687b6790b8394005d
Source dataset
uspto-grants-2015_12
Patent number
US09221786B2

Reaction notes

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