Hydrogen Bromide → HCID 117676185, compound

Participants

Reaction Steps

A solution of compound (29b) (6.7 g, 31.3 mmol) in 40% hydrobromic acid (18.4 mL, 125 mmol) was treated with an aqueous solution (38 mL) of sodium nitrite (2.4 g, 33.8 mmol), CuBr (2.5 g, 17.5 mmol), and 96% sulfuric acid (0.1 mL) in the same manner as in (i) above. The obtained product was further dissolved in methanol (100 mL), and a catalytic amount of concentrated hydrochloric acid (0.2 mL) was added thereto and treated in the same manner. The obtained residue was subjected to silica gel column chromatography and elution with an n-hexane/ethyl acetate (4:1) solution to give 6.1 g (70%) of compound (30b) as pale yellow liquid matter.

Provenance & Evidence