Benzenesulfonyl chloride → HCID 86693763, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 2-aminobenzo(b)thiophene-3-carboxylate (0.165 g) and benzenesulphonyl chloride (0.53 g) in pyridine (7 ml) was stirred and heated at 80° C. for 5 hours. Further benzenesulphonyl chloride (0.53 g) was added and the mixture was stirred and heated at 80° C. for 24 hours. The mixture was concentrated and the residue was partitioned between ethyl acetate and water. The aqueous layer was further extracted with ethyl acetate and the combined organic layers were washed with water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness and the residue was purified by chromatography on silica eluting with a mixture of ethyl acetate and pentane (5-10%) to give ethyl 2-[bis-(benzenesulphonyl)amino]benzo[b]thiophene-3-carboxylate (0.173 g) as a colourless oil.

Provenance & Evidence