Phenylmethanesulfonyl chloride → Ethyl 2-[(benzylsulfonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

HRID 1506905Notes

Reaction equation

C1([S:7]([NH:10][C:11]2[S:15][C:14]3[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[C:12]=2[C:20]([O:22][CH2:23][CH3:24])=[O:21])(=[O:9])=[O:8])C=CC=CC=1.[C:25]1([CH2:31]S(Cl)(=O)=O)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[C:25]1([CH2:31][S:7]([NH:10][C:11]2[S:15][C:14]3[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[C:12]=2[C:20]([O:22][CH2:23][CH3:24])=[O:21])(=[O:8])=[O:9])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

Reactant 2

HCID 74740Phenylmethanesulfonyl chloride

HCID 391240Ethyl 2-(benzenesulfonamido)-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate

Product 1

HCID 1311440Ethyl 2-[(benzylsulfonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

Procedure

Prepared by proceeding in a similar manner to Intermediate 1, starting from ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxlyate and phenylmethanesulphonyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-057d8a5940f74177b2948af83e7f876f
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221787B2

Reaction notes

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