Benzenesulfonyl chloride → HCID 68278757, compound

HRID 1506907Notes

Reaction equation

HRID 1506907 reaction equation
[C:1]1([S:7](NC2SC3CCCCC=3C=2C(OCC)=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:25][C:26]1[S:30][C:29]2[CH2:31][CH2:32][C:33]([CH3:36])([CH3:35])[CH2:34][C:28]=2[C:27]=1[C:37]([O:39][CH2:40][CH3:41])=[O:38].C1(S(Cl)(=O)=O)C=CC=CC=1>>[CH3:36][C:33]1([CH3:35])[CH2:32][CH2:31][C:29]2[S:30][C:26]([NH:25][S:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)(=[O:9])=[O:8])=[C:27]([C:37]([O:39][CH2:40][CH3:41])=[O:38])[C:28]=2[CH2:34]1

Participants

4

Reactant 3

HCID 7369Benzenesulfonyl chlorideHCID 391240Ethyl 2-(benzenesulfonamido)-4,5,6,7-tetrahydrobenzothiophene-3-carboxylateHCID 68278876HCID 68278876, compound

Product 1

HCID 68278757HCID 68278757, compound

Procedure

Prepared by proceeding in a similar manner to Intermediate 1, starting from ethyl 2-amino-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (prepared according to Pinkerton et al., Bioorg. Med. Chem. Lett., 2007, 17, 3562-3569) and benzenesulphonyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2963a15859594b8e880c41509ce0e167
Source dataset
uspto-grants-2015_12
Patent number
US09221787B2

Reaction notes

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