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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1506913Generated: October 29, 2026

Ethyl cyanoacetate → ethyl 2-amino-5-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxylate

https://huagongshe.com/reaction/1506913

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl cyanoacetateHCID 7764—
ReactantSulfurHCID 5362487—
ReactantEthyl 2-amino-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylateHCID 10987982—
Reactant2-(Oxan-4-yl)acetaldehydeHCID 17750943—
Productethyl 2-amino-5-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxylateHCID 59542499—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 7, starting from (tetrahydropyran-4-yl)acetaldehyde, sulphur and ethyl cyanoacetate

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09221787B2
Source datasetuspto-grants-2015_12
ORD IDord-fa85a61a94ef4ff39c92505cae3268cd
Source noteuspto-grants-2015_12