Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate → HCID 68278779, compound

HRID 1506917Notes

Reaction equation

HRID 1506917 reaction equation
FC(F)(F)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH:12][C:13]1[S:17][C:16]2[CH2:18][CH2:19][CH2:20][CH2:21][C:15]=2[C:14]=1[C:22]([O:24][CH2:25][CH3:26])=[O:23])(=[O:11])=[O:10].C(OC(C1C2CCCCC=2SC=1N)=O)C.C1(S(Cl)(=O)=O)CCCCC1>>[CH:4]1([S:9]([NH:12][C:13]2[S:17][C:16]3[CH2:18][CH2:19][CH2:20][CH2:21][C:15]=3[C:14]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])(=[O:11])=[O:10])[CH2:3][CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

4

Reactant 3

HCID 78262Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylateHCID 237554Cyclohexanesulfonyl chlorideHCID 68278820HCID 68278820, compound

Product 1

HCID 68278779HCID 68278779, compound

Procedure

Prepared by proceeding in a similar manner to Intermediate 27, starting from ethyl-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate and cyclohexanesulphonyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a86ba6aea7594461af3f256868bd4c49
Source dataset
uspto-grants-2015_12
Patent number
US09221787B2

Reaction notes

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