Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate → HCID 68278840, compound

HRID 1506925Notes

Reaction equation

HRID 1506925 reaction equation
FC(F)(F)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH:12][C:13]1[S:17][C:16]2[CH2:18][CH2:19][CH2:20][CH2:21][C:15]=2[C:14]=1[C:22]([O:24][CH2:25][CH3:26])=[O:23])(=[O:11])=[O:10].NC1SC2CCCCC=2C=1C(OCC)=O.[Br:44]C1C=CC=CC=1S(Cl)(=O)=O>>[Br:44][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH:12][C:13]1[S:17][C:16]2[CH2:18][CH2:19][CH2:20][CH2:21][C:15]=2[C:14]=1[C:22]([O:24][CH2:25][CH3:26])=[O:23])(=[O:10])=[O:11]

Participants

4

Reactant 3

HCID 78262Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylateHCID 5204032-Bromobenzenesulfonyl chlorideHCID 68278820HCID 68278820, compound

Product 1

HCID 68278840HCID 68278840, compound

Procedure

Prepared by proceeding in a similar manner to Intermediate 27, starting from ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (2.00 g) and 2-bromobenzenesulphonyl chloride (4.50 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3bfad0c750d64d048460bdcdcf09bc7f
Source dataset
uspto-grants-2015_12
Patent number
US09221787B2

Reaction notes

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