Methanol → HCID 11063366, compound

Participants

Reaction Steps

To a 250 ml round-bottomed flask, 2-Chlorocinnamic acid (25 g, 136.9 mmol) and MeOH(56 ml) were added. POCl3 (1.27 ml, 13.6 mmol) was added dropwise. The reaction mixture was stirred under reflux for 3˜4 h. The reaction mixture was cooled to room temperature, quenched with 1N NaOH solution. The mixture was extracted by EtOAc and washed with H2O. The aqueous layer was further extracted with EtOAc. The combined organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under vacuum. (26.98 g, 85˜97%)

Provenance & Evidence