HCID 90018303, compound → HCID 90019176, compound

HRID 1506957Notes

Reaction equation

HRID 1506957 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C@@H:10]1[O:14][C:13]([CH3:16])([CH3:15])[O:12][C@H:11]1[CH2:17][OH:18])([O-])=O.[N+](C1C=CC=CC=1[C@H]1OC(C)(C)O[C@@H]1CO)([O-])=O>>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C@@H:10]1[O:14][C:13]([CH3:15])([CH3:16])[O:12][C@H:11]1[CH2:17][OH:18]

Participants

3

Reactant 2

HCID 90018303HCID 90018303, compoundHCID 90018582HCID 90018582, compound

Product 1

HCID 90019176HCID 90019176, compoundYield 70%

Procedure

The substantially same method as described in Example 47 was conducted, except that (4S,5S)-methyl-5-(2-nitrophenyl)-2,2-dimethyl-1.3-dioxolane-4-carboxylate (Preparation example 50) was used instead of (4R,5R)-5-(2-nitrophenyl)-2,2-dimethyl-1.3-dioxolane-4-yl)methanol (Preparation example 46), to obtain the title compound (11 g, 70˜95%)

Sources & evidence

ORD record
ord-152f7aae459c4ee884c83a90247d51af
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

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