HCID 90018036, compound → HCID 118141632, compound

HRID 1506960Notes

Reaction equation

HRID 1506960 reaction equation
[CH3:1][O:2][C:3](=[O:15])[C@@H:4]([OH:14])[C@@H:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[F:13])[OH:6].CO[C:18](=O)[C@@H:19](O)[C@@H](C1C=CC=CC=1Cl)O>>[CH3:1][O:2][C:3]([C@@H:4]1[C@@H:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[F:13])[O:6][CH:18]([CH3:19])[O:14]1)=[O:15]

Participants

3

Reactant 2

HCID 90018036HCID 90018036, compoundHCID 90018323HCID 90018323, compound

Product 1

HCID 118141632HCID 118141632, compoundYield 70%

Procedure

The substantially same method as described in Example 60 was conducted, except that (2S,3R)-methyl-3-(2-fluorophenyl)-2,3-dihydroxypropanoate (Preparation example 81) was used instead of ((2S,3R)-methyl-3-(2-chlorophenyl)-2,3-dihydroxypropanoate, to obtain the title compound (3.1 g, 70˜95%).

Sources & evidence

ORD record
ord-1e9f06f6cc04474b9705c852f2dd351d
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

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