HCID 6105229, compound → HCID 13815773, compound

Participants

Reaction Steps

To stirred solution of LAH(LiAlH4, 3.3 g, 86.73 mmol) in THF(66 mL) was added dropwise a solution (E)-5-phenylpent-3-enoic acid (Preparation example 235, 11.0 g, 57.82 mmol) in THF(44 mL) at 0° C. then stirred at room temperature for 1 h. The reaction mixture was quenched with H2O at 0° C., filtered through celite, washed with EtOAc, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated. The crude compound was purified by a silica gel column to produce the title compound (7.2 g, 70˜90%)

Provenance & Evidence