HCID 90026583, compound → HCID 118151805, compound

HRID 1506968Notes

Reaction equation

HRID 1506968 reaction equation
C([O:7][CH2:8][CH2:9][C@@H:10]1[C@@H:14]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[O:13][C:12]([CH2:24][CH3:25])([CH2:22][CH3:23])[O:11]1)(=O)C(C)(C)C.C(OCC[C@H]1[C@H](CC2C=CC=CC=2)OC(CC)(CC)O1)(=O)C(C)(C)C>>[CH2:15]([C@H:14]1[O:13][C:12]([CH2:22][CH3:23])([CH2:24][CH3:25])[O:11][C@@H:10]1[CH2:9][CH2:8][OH:7])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 90026583HCID 90026583, compoundHCID 118379061HCID 118379061, compound

Product 1

HCID 118151805HCID 118151805, compoundYield 80%

Procedure

The substantially same method as described in Example 247 was conducted, except that (2-((4R,5R)-5-benzyl-2,2-diethyl-1,3-dioxolan-4-yl)ethyl pivalate (Preparation example 249) was used instead of (2-((4S,5S)-5-benzyl-2,2-diethyl-1,3-dioxolan-4-yl)ethyl pivalate (Preparation example 246), to obtain the title compound (0.9 g, 80˜95%)

Sources & evidence

ORD record
ord-b6e8d4a7f61042758fd2fd26cf265d02
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

Loading…