HCID 90026583, compound → HCID 118379084, compound

HRID 1506969Notes

Reaction equation

HRID 1506969 reaction equation
C([O:7][CH2:8][CH2:9][C@H:10]1[C@H:14]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[O:13][C:12]2([CH2:25][CH2:24][CH2:23][CH2:22]2)[O:11]1)(=O)C(C)(C)C.C(OCC[C@H]1[C@H](CC2C=CC=CC=2)OC(CC)(CC)O1)(=O)C(C)(C)C>>[CH2:15]([C@@H:14]1[O:13][C:12]2([CH2:25][CH2:24][CH2:23][CH2:22]2)[O:11][C@H:10]1[CH2:9][CH2:8][OH:7])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 90026583HCID 90026583, compoundHCID 118379151HCID 118379151, compound

Product 1

HCID 118379084HCID 118379084, compoundYield 80%

Procedure

The substantially same method as described in Example 247 was conducted, except that 2-((2S,3S)-3-benzyl-1,4-dioxaspiro[4.4]nonan-2-yl)ethyl pivalate (Preparation example 251) was used instead of (2-((4S,5S)-5-benzyl-2,2-diethyl-1,3-dioxolan-4-yl)ethyl pivalate (Preparation example 246), to obtain the title compound (0.7 g, 80˜95%)

Sources & evidence

ORD record
ord-d0a08307b35a4004b0458ad01461104b
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

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