HCID 90025945, compound → HCID 118151829, compound

HRID 1506974Notes

Reaction equation

HRID 1506974 reaction equation
C([Si]([O:8][CH2:9][CH2:10][C@H:11]1[C@H:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[O:14][C:13]([CH3:23])([CH3:22])[O:12]1)(C)C)(C)(C)C.C([Si](OCC[C@@H]1[C@@H](C2C=CC=CC=2)OC(C)(C)O1)(C)C)(C)(C)C>>[C:16]1([C@@H:15]2[O:14][C:13]([CH3:22])([CH3:23])[O:12][C@H:11]2[CH2:10][CH2:9][OH:8])[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 90025945HCID 90025945, compoundHCID 90033623HCID 90033623, compound

Product 1

HCID 118151829HCID 118151829, compoundYield 80%

Procedure

The substantially same method as described in Example 285 was conducted, except that tert-butyl(2-((4S,5S)-5-phenyl-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)dimethylsilane (Preparation example 288) was used instead of that tert-butyl(2-((4R,5R)-5-phenyl-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)dimethylsilane (Preparation example 284), to obtain the title compound (0.4 g, 80˜95%)

Sources & evidence

ORD record
ord-6c5bc6b6da0344bbb1a1a4d092d7c68f
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

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