HCID 118379162, compound → HCID 118151731, compound

HRID 1506975Notes

Reaction equation

HRID 1506975 reaction equation
C([O:7][CH2:8][CH2:9][C@@H:10]1[C@@H:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[O:13][C:12]2([CH2:24][CH2:23][CH2:22][CH2:21]2)[O:11]1)(=O)C(C)(C)C.C(OCC[C@@H]1[C@@H](C2C=CC=CC=2)OC(CC)(CC)O1)(=O)C(C)(C)C>>[C:15]1([C@H:14]2[O:13][C:12]3([CH2:24][CH2:23][CH2:22][CH2:21]3)[O:11][C@@H:10]2[CH2:9][CH2:8][OH:7])[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 118379162HCID 118379162, compoundHCID 118379197HCID 118379197, compound

Product 1

HCID 118151731HCID 118151731, compoundYield 80%

Procedure

The substantially same method as described in Example 291 was conducted, except that 2-((2R,3R)-3-phenyl-1,4-dioxaspiro[4.4]nonan-2-yl)ethyl pivalate (Preparation example 292) was used instead of that 2-((4S,5S)-2,2-diethyl-5-phenyl-1,3-dioxolan-4-yl)ethyl pivalate (Preparation example 290), to obtain the title compound (0.9 g, 80˜95%)

Sources & evidence

ORD record
ord-457c0975bc4e47529ecb7b724c9f90c1
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

Loading…