HCID 118151732, compound → HCID 118151814, compound

HRID 1506976Notes

Reaction equation

HRID 1506976 reaction equation
C([O:7][CH2:8][CH2:9][C@@H:10]1[C@@H:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[O:13][C:12]2([CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[O:11]1)(=O)C(C)(C)C.C(OCC[C@@H]1[C@@H](C2C=CC=CC=2)OC2(CCCC2)O1)(=O)C(C)(C)C>>[C:15]1([C@H:14]2[O:13][C:12]3([CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[O:11][C@@H:10]2[CH2:9][CH2:8][OH:7])[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 118151732HCID 118151732, compoundHCID 118379162HCID 118379162, compound

Product 1

HCID 118151814HCID 118151814, compoundYield 80%

Procedure

The substantially same method as described in Example 293 was conducted, except that 2-((2R,3R)-3-phenyl-1,4-dioxaspiro[4.5]decan-2-yl)ethyl pivalate (Preparation example 294) was used instead of that 2-((2R,3R)-3-phenyl-1,4-dioxaspiro[4.4]nonan-2-yl)ethyl pivalate (Preparation example 292), to obtain the title compound (1.2 g, 80˜95%)

Sources & evidence

ORD record
ord-1eec3447a99d436a9e7a772e1b31bb34
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

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