HCID 123225194, compound → HCID 118151876, compound

HRID 1506981Notes

Reaction equation

HRID 1506981 reaction equation
C([Si]([O:8][CH2:9][CH2:10][C@H:11]1[C@H:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])[O:14][C:13]([CH3:24])([CH3:23])[O:12]1)(C)C)(C)(C)C.C([Si](OCC[C@@H]1[C@@H](C2C=CC=CC=2Cl)OC(C)(C)O1)(C)C)(C)(C)C>>[Cl:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[C@@H:15]1[O:14][C:13]([CH3:23])([CH3:24])[O:12][C@H:11]1[CH2:10][CH2:9][OH:8]

Participants

3

Reactant 2

HCID 123225194HCID 123225194, compoundHCID 123785902HCID 123785902, compound

Product 1

HCID 118151876HCID 118151876, compoundYield 80%

Procedure

The substantially same method as described in Example 352 was conducted, except that tert-butyl(2-((4S,5S)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)dimethylsilane (Preparation example 355) was used instead of that tert-butyl(2-((4R,5R)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)dimethyl silane (Preparation example 351), to obtain the title compound (0.3 g, 80˜95%).

Sources & evidence

ORD record
ord-0cb093cb92264d4daf6e1552725a00bd
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

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