HCID 118151943, compound → HCID 118151747, compound

HRID 1506983Notes

Reaction equation

HRID 1506983 reaction equation
C([O:7][CH2:8][CH2:9][C@H:10]1[C@H:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[O:13][C:12]2([CH2:25][CH2:24][CH2:23][CH2:22]2)[O:11]1)(=O)C(C)(C)C.C(OCC[C@H]1[C@H](C2C=CC=CC=2Cl)OC(CC)(CC)O1)(=O)C(C)(C)C>>[Cl:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C@@H:14]1[O:13][C:12]2([CH2:25][CH2:24][CH2:23][CH2:22]2)[O:11][C@H:10]1[CH2:9][CH2:8][OH:7]

Participants

3

Reactant 2

HCID 118151943HCID 118151943, compoundHCID 118379182HCID 118379182, compound

Product 1

HCID 118151747HCID 118151747, compoundYield 80%

Procedure

The substantially same method as described in Example 364 was conducted, except that 2-((2S,3S)-3-(2-chlorophenyl)-1,4-dioxaspiro[4.4]nonan-2-yl)ethyl pivalate (Preparation example 365) was used instead of that 2-((4S,5S)-2,2-diethyl-5-(2-chlorophenyl)-1,3-dioxolan-4-yl)ethyl pivalate (Preparation example 363), to obtain the title compound (0.4 g, 80˜95%)

Sources & evidence

ORD record
ord-17069d8162fc4605a18fa7b3b87a894c
Source dataset
uspto-grants-2015_12
Patent number
US09221783B2

Reaction notes

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