HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+/-)-3-(Benzyloxy)-1-(2-chlorophenyl)propane-1,2-diol → (4S,5R)-4-(benzyloxymethyl)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+/-)-3-(Benzyloxy)-1-(2-chlorophenyl)propane-1,2-diol | HCID 90026408 | — |
| Reactant | (1S,2R)-3-(benzyloxy)-1-(2-chlorophenyl)propane-1,2-diol | HCID 118379121 | — |
| Product | (4S,5R)-4-(benzyloxymethyl)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolane | HCID 118379134 | 85% |
Reaction Steps
The substantially same method as described in Example 371 was conducted, except that (1S,2R)-3-(benzyloxy)-1-(2-chlorophenyl)propane-1,2-diol (Preparation example 375) was used instead of that (±)-3-(benzyloxy)-1-(2-chlorophenyl)propane-1,2-diol (Preparation example 370), to obtain the title compound (0.84 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221783B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-48f6a140372f46cfa46ad30b0e09c159 |
| Source note | uspto-grants-2015_12 |