HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+/-)-4-(Benzyloxymethyl)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolane → ((4S,5R)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+/-)-4-(Benzyloxymethyl)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolane | HCID 90027002 | — |
| Reactant | (4S,5R)-4-(benzyloxymethyl)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolane | HCID 118379134 | — |
| Product | ((4S,5R)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol | HCID 118151846 | 95% |
Reaction Steps
The substantially same method as described in Example 372 was conducted, except that ((4S,5R)-4-(benzyloxymethyl)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolane (Preparation example 376) was used instead of that (±)-4-(benzyloxymethyl)-5-(2-chlorophenyl)-2,2-dimethyl-1,3-dioxolane (Preparation example 371), to obtain the title compound (0.58 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221783B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-c5810e248fb84b3c8b0e1e05496981c4 |
| Source note | uspto-grants-2015_12 |