Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 2-Bromopyridine | HCID 7973 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 3-(Methoxycarbonyl)benzeneboronic acid | HCID 2734714 | — |
| Katalysator | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | Methyl 3-(pyridin-2-yl)benzoate | HCID 3364101 | 74% |
Reaktionsschritte
A solution (3-(methoxycarbonyl)phenyl)boronic acid (500 mg, 2.78 mmol), 2-bromopyridine (399 mg, 2.53 mmol), K2CO3 (1.0 g, 7.6 mmol) and Pd(dppf)Cl2 (20 mg) in a mixture of dioxane (10 mL) and water (2.5 mL) was heated under microwave conditions at 120° C. for 0.5 h. The reaction mixture was filtered, concentrated, and the crude product was purified by column chromatography eluting with petroleum ether/ethyl acetate (5:1). (400 mg, yield 74%) MS (ESI+) e/z: 214.1 [M+1]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US09221794B2 |
|---|
| Quelldatensatz | uspto-grants-2015_12 |
|---|
| ORD ID | ord-0b4e1e0d49e1428c9bf921991d0bb71f |
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| Quellennotiz | uspto-grants-2015_12 |
|---|
