反应详情

To a solution of methyl 3-(pyridin-2-yl)benzoate (400 mg, 1.88 mmol) in MeOH (3 mL) was added aqueous of NaOH (1 mL, 40 mol %). The reaction mixture was stirred at room temperature for 3 h and concentrated. The crude residue was dissolved in water and the pH was adjusted to 5˜6 with 2N of HCl. The solution was extracted with ethyl acetate, brine, dried over sodium sulfate, filtered and concentrated. (350 mg, yield 93%) MS (ESI+) e/z: 200.1 [M+1]+.

1. concentrationconcentrated
2. dissolutionThe crude residue was dissolved in water
3. extractionThe solution was extracted with ethyl acetate, brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated