8-Hydroxyquinoline → Ethyl (quinolin-8-yloxy)acetate

Participants

Reaction Conditions

Reaction Steps

To a solution of quinolin-8-ol (3 g, 0.0207 mol) in MeCN (10 mL) was added ethyl bromoacetate (4.12 g, 0.025 mol) and K2CO3 (5.75 g, 0.0414 mol). The mixture was stirred at 80° C. for 12 h, filtered and concentrated. The crude residue was purified by column chromatography. (3.9 g, yield, 82%) MS (ESI+) e/z: 232.1 [M+1]+.

Provenance & Evidence