Hydrogen chloride-ethyl acetate → HCID 76902416, compound

Participants

Reaction Steps

To a solution of tert-butyl cyclopentyl(3-(2-hydroxy-3-(isoindolin-2-yl) propoxy) benzyl)carbamate (200 mg, 0.43 mmol) in ethyl acetate (10 mL) was added HCl/ethyl acetate (5 mL) at 0° C. After 4 h, the reaction mixture was concentrated and purified by preparative HPLC purification. (90 mg, yield 57%) MS (ESI+) e/z: 367.3 [M+1]+. 1H NMR (MeOD, 400 MHz), δ ppm: 7.42-7.37 (m, 5H), 7.15-7.05 (m, 3H), 4.72-4.59 (m, 4H), 4.48-4.42 (m, 1H), 4.18 (s, 2H), 4.11-4.08 (m, 2H), 3.74-3.30 (m, 3H), 2.19-2.12 (m, 2H), 1.84-1.65 (m, 6H).

Provenance & Evidence