HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1507062Generated: November 1, 2026
2-(Methylsulfonyl)ethyl methanesulfonate → HCID 24888497, compound
https://huagongshe.com/reaction/1507062
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(Methylsulfonyl)ethyl methanesulfonate | HCID 18464597 | — |
| Reactant | N-(4-(2-aminoethoxy)-3-(1-methyl-1H-pyrazol-5-yl)phenyl)-3-methoxybenzamide | HCID 46833678 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 24888497 | HCID 24888497 | 18.5% |
Reaction Steps
A mixture of 2-(methylsulfonyl)ethyl methanesulfonate (16.6 mg, 81.9 μmol) and N-(4-(2-aminoethoxy)-3-(1-methyl-1H-pyrazol-5-yl)phenyl)-3-methoxybenzamide (30 mg, 81.9 μmol) in DMF was heated to 150° C. for 1 hour under microwave irradiation in a heavy-walled sealed tube. The crude product was purified by HPLC. The proper fractions were collected and lyophilized to afford the title compound as a yellow solid in 18.5% yield. LCMS m/z (%)=473 (M+H, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09221755B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-652b3b49093346f8be634722d0a48514 |
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| Source note | uspto-grants-2015_12 |
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