2-(Bromomethyl)tetrahydro-2H-pyran → 1'-{[5-(trifluoromethyl)furan-2-yl]methyl}-3,4-dihydro-2H-spiro[furo[2,3-h][1,5]benzodioxepine-9,3'-indol]-2'(1'H)-one

HRID 150712Notes

Reaction equation

HRID 150712 reaction equation
[Br:24][CH2:25][c:26]1[o:27][c:28]([C:31]([F:32])([F:33])[F:34])[cH:29][cH:30]1.[Br:35][CH2:36][CH:37]1[CH2:38][CH2:39][CH2:40][CH2:41][O:42]1.[NH:1]1[C:2](=[O:23])[C:3]2([CH2:4][O:5][c:6]3[c:7]2[cH:8][c:9]2[c:10]([cH:16]3)[O:11][CH2:12][CH2:13][CH2:14][O:15]2)[c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]21>>[N:1]1([CH2:25][c:26]2[o:27][c:28]([C:31]([F:32])([F:33])[F:34])[cH:29][cH:30]2)[C:2](=[O:23])[C:3]2([CH2:4][O:5][c:6]3[c:7]2[cH:8][c:9]2[c:10]([cH:16]3)[O:11][CH2:12][CH2:13][CH2:14][O:15]2)[c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]21

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 461939253,4-dihydro-2H-spiro[furo[2,3-h][1,5]benzodioxepine-9,3'-indol]-2'(1'H)-one

Product 1

HCID 461939241'-{[5-(trifluoromethyl)furan-2-yl]methyl}-3,4-dihydro-2H-spiro[furo[2,3-h][1,5]benzodioxepine-9,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-8cf17109a33c4187bd46ffe97f705f74
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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