(4aS,7aR)-Hexahydro-cyclopenta[d][1,3]oxazin-2-one → (4aS,7aR)-1-[5-(3-Fluorophenylethynyl)-pyridin-2-yl]-hexahydro-cyclopenta[d][1,3]oxazin-2-one

Participants

Reaction Steps

The title compound was prepared in accordance with the general method of Example 1, step 4 using (4aS,7aR)-hexahydro-cyclopenta[d]-[1,3]oxazin-2-one (66 mg, 0.47 mmol) (Example 1, step 2) and 2-fluoro-5-((3-fluorophenyl)ethynyl)pyridine (100 mg, 0.47 mmol) to yield 48 mg (31%) of the title compound as a light yellow amorphous solid; MS: m/e=337.3 (M+H+).

Provenance & Evidence