N,N-Diethyl-1,4-butanediamine → HCID 90375180, compound

HRID 1507157Notes

Reaction equation

HRID 1507157 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:9][CH3:10])[CH2:7][CH3:8].[CH2:11]([O:13][C:14]([C:16]1[CH:21]=[CH:20][N:19]=[C:18]([CH2:22][N:23]([CH2:30][C:31](O)=[O:32])[C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])[CH:17]=1)=[O:15])[CH3:12]>>[CH2:7]([N:6]([CH2:9][CH3:10])[CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:31]([CH2:30][N:23]([CH2:22][C:18]1[CH:17]=[C:16]([C:14]([O:13][CH2:11][CH3:12])=[O:15])[CH:21]=[CH:20][N:19]=1)[C:24](=[O:29])[C:25]([F:26])([F:27])[F:28])=[O:32])[CH3:8]

Participants

3

Reactant 2

HCID 117976N,N-Diethyl-1,4-butanediamineHCID 90094027HCID 90094027, compound

Product 1

HCID 90375180HCID 90375180, compound

Procedure

By General procedure Y from (4-aminobutyl)diethylamine and 2-(N-{[4-(ethoxycarbonyl)pyridin-2-yl]methyl}-2,2,2-trifluoroacetamido)acetic acid. Purification by column chromatography gave the title compound as oil. 1H NMR (300 MHz, chloroform-d): δ ppm 9.09 (t, 1H), 8.67 (m, 1H), 7.83 (m, 2H), 4.85 (m, 2H), 4.42 (q, 2H), 4.17 (m, 2H), 3.26 (m, 2H), 2.46 (m, 6H), 1.52 (m, 4H), 1.40 (t, 3H), 0.97 (m, 6H).

Workup

  1. customPurification by column chromatography

Sources & evidence

ORD record
ord-6c8bbd2645234034a357ea91a49e1f77
Source dataset
uspto-grants-2015_12
Patent number
US09221801B2

Reaction notes

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