Sodium hydride → 3-Bromo-1-(3-fluoro-4-methyl-benzyl)pyrrolidin-2-one

Participants

Reaction Steps

To a stirring suspension of NaH (0.76 g, 19 mmol) in tetrahydrofuran (50 mL) was added dropwise over ˜½ hour a solution of 2,4-dibromo-N-(3-fluoro-4-methylbenzyl)butanamide (4.5 g, 12.2 mmol) in tetrahydrofuran (30 mL) and the resulting mixture was stirred at room temperature overnight. The reaction mixture was then filtered and the solvent evaporated.

Provenance & Evidence