HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(4-Methoxyphenyl)-1,2,3,6-tetrahydropyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Tert-butyl 4-hydroxy-4-(4-methoxyphenyl)piperidine-1-carboxylate | HCID 49760247 | — |
| Product | 4-(4-Methoxyphenyl)-1,2,3,6-tetrahydropyridine hydrochloride | HCID 21473670 | — |
Reaction Steps
A mixture of tert-butyl 4-hydroxy-4-(4-methoxyphenyl)piperidine-1-carboxylate (700 mg, 2.27 mmol) from Step A and HCl in dioxane (4 ml, 16 mmol) was stirred at rt for 3 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221796B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-f1169173ede0446ba15aee865946d204 |
| Source note | uspto-grants-2015_12 |