HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3R,4R)-4-(4-(Benzyloxy)phenyl)piperidin-3-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl (3R,4R)-4-(4-benzyloxyphenyl)-3-hydroxy-piperidine-1-carboxylate | HCID 52910991 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3R,4R)-4-(4-(Benzyloxy)phenyl)piperidin-3-ol hydrochloride | HCID 118207402 | — |
Reaction Steps
A mixture of (3R,4R)-tert-butyl 4-(4-(benzyloxy)phenyl)-3-hydroxypiperidine-1-carboxylate (750 mg, 2 mmol), dioxane (4 mL) and 4.9 mL of 4 M HCl in dioxane was stirred at rt for 2 h. The reaction was then evaporated to dryness to yield 550 mg of (3R,4R)-4-(4-(Benzyloxy)phenyl)piperidin-3-ol hydrochloride which was used without further purification. LCMS (method J) RT 0.70 min, m/z 284 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221796B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-cc7ae950661244f688dbcc3d97b42e8f |
| Source note | uspto-grants-2015_12 |