Trifluoroacetic acid → 4-((3R,4R)-3-fluoropiperidin-4-yl)phenol trifluoroacetate

Participants

Reaction Steps

To a solution of (3R,4R)-tert-butyl 3-fluoro-4-(4-hydroxyphenyl)piperidine-1-carboxylate (120 mg, 0.41 mmol) in 1.5 mL DCM at rt was added TFA (0.5 mL, 6.5 mmol), and the mixture was stirred for 3 h. The mixture was then concentrated in vacuo to dryness to yield 4-((3R,4R)-3-fluoropiperidin-4-yl)phenol trifluoroacetate (126 mg, 0.41 mmol), which was used directly in step D.

Provenance & Evidence