Trifluoroacetic acid → 3,3-Difluoro-4-(4-methoxyphenyl)piperidine trifluoroacetate

Participants

Reaction Steps

To a solution of (R)-t-butyl 3,3-difluoro-4-(4-methoxyphenyl)piperidine-1-carboxylate (65 mg, 0.2 mmol) in DCM (0.8 mL) was added TFA (0.4 mL, 5.2 mmol) at rt. The mixture was stirred for 2 h, then concentrated to dryness in vacuo to afford crude 3,3-difluoro-4-(4-methoxyphenyl)piperidine trifluoroacetate (67.8 mg, 0.2 mmol, 100% yield), which was used in step G without further purification.

Provenance & Evidence