Trifluoroacetic acid → HCID 118005805, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-((4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(hydroxy)methyl)piperidine-1-carboxylate (110 mg, 0.19 mmol, Intermediate 11: step a) in DCM (5 mL) was added TFA (75 μL, 0.97 mmol). The resulting solution was stirred at room temperature for 2 hours. TFA (75 μL, 0.97 mmol) was added and the mixture stirred at room temperature overnight. Then the reaction was diluted with DCM, cooled to 0° C., and the pH adjusted to ˜pH 8 by the addition of 3 N aqueous NaOH dropwise. The layers were separated and the organics dried (MgSO4), filtered and concentrated to dryness to afford the title compound which was used without further purification.

Provenance & Evidence