2,6-Dimethylnicotinaldehyde → {2-Azetidin-1-yl-4-chloro-3-[4-(trifluoromethyl)benzyl]quinolin-6-yl}(2,6-dimethylpyridin-3-yl)methanol

Participants

Reaction Conditions

Reaction Steps

2-(Azetidin-1-yl)-6-bromo-4-chloro-3-(4-(trifluoromethyl)benzyl)quinoline (1.09 g, 2.40 mmol, Intermediate 16) was dissolved in THF (20 mL) in a dry round bottom flask under an N2 atmosphere, then cooled to −78° C. in dry ice acetone bath. n-BuLi (1.6 M in hexanes, 1.74 mL, 2.79 mmol) was then added dropwise via syringe over approximately 5 minutes. The contents were stirred at −78° C. for approximately 10 minutes, then a solution of 2,6-dimethyl-pyridine-3-carbaldehyde (0.36 g, 2.6 mmol) in THF (20 mL) was added via cannula and stirred for 10 minutes at −78° C. The dry ice bath was then removed and replaced with an ice water bath and stirred at 0° C. for approximately one hour. The reaction was then quenched with a saturated, aqueous NH4Cl solution then transferred to a separatory funnel with EtOAc. The organic phase was extracted with a saturated, aqueous NH4Cl solution and deionized water, then separated and dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by flash column chromatography (silica gel, 0-100% DCM/(10% of a 2 M NH3 MeOH in DCM)) to afford the title compound. MS (ESI): mass calcd. for C28H25ClF3N3O, 511.2; m/z found, 512.5 [M+H]+. 1H NMR (400 MHz, CDCl3) δ ppm 7.99 (d, J=2.0 Hz, 1H), 7.75 (d, J=7.9 Hz, 1H), 7.69 (d, J=8.6 Hz, 1H), 7.53 (d, J=8.1 Hz, 2H), 7.44 (dd, J=8.7, 2.0 Hz, 1H), 7.24-7.18 (m, 2H), 7.04 (d, J=7.9 Hz, 1H), 6.09 (s, 1H), 4.34 (s, 2H), 4.12 (t, J=7.6 Hz, 4H), 2.74 (s, 1H), 2.51 (s, 3H), 2.46 (s, 3H), 2.29-2.18 (m, 2H).

Provenance & Evidence