HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → Ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | 2-Chloro-6-methoxyquinoline | HCID 83647 | — |
| Product | Ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate | HCID 66980031 | — |
Reaction Steps
Ethyl piperidine-4-carboxylate (100 mg) was treated with 2-chloro-6-methoxyquinoline (Intermediate 1) (90 mg) in MeCN (0.8 mL) and TEA (100 mg) in a sealed tube at 180° C. for 6 h in a microwave reactor. After aqueous work-up with EtOAc and column purification, eluting with EtOAc/hexane, ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate (90 mg) was afforded as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221810B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-5483819f7a624397a223307a3ab3f399 |
| Source note | uspto-grants-2015_12 |