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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1507358Generated: October 31, 2026

2-Chloroquinolin-6-ol → 4-(6-Hydroxyquinolin-2-yl)-3-(trifluoromethyl)benzoic acid

https://huagongshe.com/reaction/1507358

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloroquinolin-6-olHCID 22132577—
ReactantMethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)benzoateHCID 66980121—
Product4-(6-Hydroxyquinolin-2-yl)-3-(trifluoromethyl)benzoic acidHCID 56959063—

Reaction Steps

Followed Scheme 3: starting with 2-chloroquinolin-6-ol and methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)benzoate (Intermediate 5).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09221810B2
Source datasetuspto-grants-2015_12
ORD IDord-d3b0664429064e97b1af34a2962d919f
Source noteuspto-grants-2015_12