4-Carboxyphenylboronic Acid → HCID 136098507, compound

HRID 1507380Notes

Reaction equation

HRID 1507380 reaction equation
Cl[C:2]1[C:11]([C:12]([F:15])([F:14])[F:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:16]C)[CH:8]=2)[N:3]=1.B([C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)(O)O>>[OH:16][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)[C:11]([C:12]([F:13])([F:14])[F:15])=[N:10]2

Participants

3

Reactant 2

HCID 3121834-Carboxyphenylboronic AcidHCID 53212388HCID 53212388, compound

Product 1

HCID 136098507HCID 136098507, compound

Procedure

Followed the procedure described for Compound VI-1, starting from Intermediate 11 and 4-boronobenzoic acid. 1H NMR (MeOH-d4 500 MHz): δ 8.07 (d, J=8.5 Hz, 2H), 7.96 (d, J=9.0 Hz, 1H), 7.61 (d, J=8.5 Hz, 2H), 7.51 (dd, J=2.5, 9.5 Hz; 1H), 7.35 (d, J=2.5 Hz, 1H); MS (ESI): m/z 335 [M+1]+.

Sources & evidence

ORD record
ord-0c6226c74f344a1ca22deb718a6084d3
Source dataset
uspto-grants-2015_12
Patent number
US09221810B2

Reaction notes

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