反应详情

Followed the procedure described in Compound W-8 step 1, starting with 3-chloro-7-methoxyisoquinoline (Intermediate 12) and 4-boronobenzoic acid with an alternative isolation procedure: After reaction was complete, the reaction mixture was diluted with H2O (10 mL). The aqueous layer was extracted with EtOAc/MeOH (v/v=10:1, 30 mL×2). Then the aqueous layer was acidified with 2M HCl to pH=6. The precipitate was collected by filtration and washed with MeOH (10 mL), dried under high vacuum to give the product.

1. customAfter reaction
2. extractionThe aqueous layer was extracted with EtOAc/MeOH (v/v=10:1, 30 mL×2)
3. filtrationThe precipitate was collected by filtration
4. washwashed with MeOH (10 mL)
5. customdried under high vacuum
6. customto give the product