Dichloromethane → HCID 117701573, compound

Participants

Reaction Steps

To a solution of benzyl 3-[7-(benzyloxy)-3,8-dimethyl-4-oxo-4H-chromen-2-yl]azetidine-1-carboxylate (625 mg, 1.33 mmol) obtained in Example 1-2 in methanol (12 mL), 10% palladium-carbon (water content: 50%, 200 mg) was added, and the mixture was stirred for 2 hours under a hydrogen atmosphere. Dichloromethane (20 mL) and methanol (20 mL) were added to the reaction solution, and the palladium-carbon was removed by filtration through celite. The filtrate was concentrated under reduced pressure to obtain 297 mg of the title compound (yield: 91%).

Provenance & Evidence