Hydrochloric Acid → HCID 117701682, compound

Participants

Reaction Steps

Potassium carbonate (97 mg, 0.70 mmol) was added to a solution of 2-[(2R)-1-ethylpyrrolidin-2-yl]-3,8-dimethyl-4-oxo-4H-chromen-7-yl acetate (58 mg, 0.18 mmol) obtained in Example 3-1 in methanol (4 mL), and then the mixture was stirred at room temperature for 2 hours. A 1 N aqueous hydrochloric acid solution (2 mL) was added dropwise thereto, and then methanol in the reaction solution was distilled off under reduced pressure. Water (2 mL) was added to the residue, and then the pH of the mixture was adjusted to around 8 by the dropwise addition of a saturated aqueous solution of sodium bicarbonate, followed by extraction with ethyl acetate. The organic layer was dried over sodium sulfate. The desiccant was filtered off, and then the filtrate was concentrated under reduced pressure. Ethyl acetate and n-hexane were added to the obtained residue, and the mixture was powdered to obtain 40 mg of the title compound (yield: 79%).

Provenance & Evidence