Hydrochloric Acid → HCID 117701692, compound

Participants

Reaction Conditions

Reaction Steps

A mixture composed of 7-hydroxy-3,8-dimethyl-2-{(2R)-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]pyrrolidin-2-yl}-4H-chromen-4-one (77 mg, 0.20 mmol) obtained in Example 4-1, methanol (6 mL), concentrated hydrochloric acid (0.5 mL), and water (1 mL) was heated with stirring at a bath temperature of 55° C. for 20 hours. The reaction solution was concentrated under reduced pressure, and the obtained residue was purified by reverse-phase HPLC. A 1 N aqueous hydrochloric acid solution (4 mL) was added to a fraction containing the compound of interest, and then the mixture was concentrated under reduced pressure. Diethyl ether and methanol were added to the obtained residue, and the mixture was powdered. The obtained solid was collected by filtration and then dried in a vacuum pump to obtain 40 mg of the title compound (yield: 53%).

Provenance & Evidence