Pyridine → HCID 71667941, compound

Participants

Reaction Steps

To a solution of 7-hydroxy-3,8-dimethyl-2-(piperidin-4-yl)-4H-chromen-4-one (68 mg, 0.25 mmol) obtained in Example 7-2 and pyridine (22 μL, 0.28 mmol) in dimethylformamide (2 mL), ethyl chlorocarbonate (24 μL, 0.25 mmol) was added dropwise under cooling with ice, and then the mixture was brought back to room temperature and stirred for 2 days. The reaction solution was concentrated, and the obtained residue was purified by reverse-phase HPLC to obtain 60 mg of the title compound (yield: 69%).

Provenance & Evidence