Ethyl isocyanate → HCID 71667943, compound

Participants

Reaction Steps

To a solution of 7-hydroxy-3,8-dimethyl-2-(piperidin-4-yl)-4H-chromen-4-one (68 mg, 0.25 mmol) obtained in Example 7-2 in dimethylformamide (2 mL), isocyanatoethane (19 μL, 0.25 mmol) was added dropwise under cooling with ice, and then the mixture was brought back to room temperature and stirred for 2 days. The reaction solution was concentrated, and then the obtained residue was purified by reverse-phase HPLC to obtain 52 mg of the title compound (yield: 59%).

Provenance & Evidence